A connection between the FACT complex and cell progression in Saccharomyces cerevisiae. Una conexión entre el complejo FACT y progresión de la célula Saccharomyces cerevisiae.
The FACT complex is an essential component of eukaryotic cells able to modify the chromatin structure allowing transcription by the RNA polymerase II. The FACT that this complex is essential in all organisms tested added to that it has been recently shown to be a target of curaxins, a potential novel anticancer compound, makes this complex an interesting subject of study. In Saccharomyces cerevisiae, this complex is essential, and mutants affected in Spt16, one of the two subunits of this complex, show a clear arrest in the G1/S transition of the cell cycle and a transcriptional defect that does not ...